Nakayama K
First Department of Surgery, Asahikawa Medical College.
Nihon Geka Gakkai Zasshi. 1992 Oct;93(10):1341-6.
In order to investigate the blood compatibility of autogenous vein graft (AVG), changes in prostacyclin (PGI2) production following harvesting and arterial implantation were studied experimentally. Basal PGI2 production, which means the value obtained without stimulation by arachidonic acid (AA), decreased significantly 60 minutes after harvesting. At this time, no morphological changes in the endothelial cells were observed. Under stimulation by AA, a significant decrease in the PGI2 production of the specimens was seen 120 minutes after harvesting. Despite severe morphological changes in endothelial cells, the PGI2 production of vein grafts was maintained until this time. The AVG in the canine abdominal aorta was completely reendothelialized 1 week after implantation, but another 2 weeks were needed to restore PGI2 production. It is concluded from these results: 1. It is rational to implant an AVG within 60 minutes after harvesting from the viewpoints of morphology and PGI2 production of the endothelial cells. 2. PGI2 production from sources other than endothelial cells is possible and may contribute to the compatibility of the AVG in the early period after implantation. 3. AVG in the aorta could restore PGI2 production 3 weeks after implantation.
为了研究自体静脉移植物（AVG）的血液相容性，实验性地研究了采集和动脉植入后前列环素（PGI2）产生的变化。基础PGI2产生量，即未受花生四烯酸（AA）刺激时获得的值，在采集后60分钟显著下降。此时，未观察到内皮细胞的形态学变化。在AA刺激下，采集后120分钟时标本的PGI2产生量显著下降。尽管内皮细胞出现严重形态学变化，但静脉移植物的PGI2产生量在此之前一直维持。犬腹主动脉中的AVG在植入后1周完全重新内皮化，但还需要另外2周才能恢复PGI2产生。从这些结果得出以下结论：1. 从内皮细胞的形态学和PGI2产生的角度来看，在采集后60分钟内植入AVG是合理的。2. 除内皮细胞外的其他来源产生PGI2是可能的，并且可能有助于植入后早期AVG的相容性。3. 主动脉中的AVG在植入后3周可恢复PGI2产生。
