Kraevskiĭ V A, Mikhaĭlov V S, Razin S V
Mol Biol (Mosk). 1992 Jul-Aug;26(4):745-56.
The importance of spatial organization of DNA for the regulation of genome activity is discussed. The main problem reviewed in this paper includes cooperative interactions of proteins with DNA, formation of DNA loops in the regulatory domains of the genome and conformational mobility of DNA in chromatin.
讨论了DNA的空间组织对基因组活性调控的重要性。本文综述的主要问题包括蛋白质与DNA的协同相互作用、基因组调控域中DNA环的形成以及染色质中DNA的构象流动性。
