Yamamoto S, Morimoto I, Yamashita H, Eto S
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Neurosci Lett. 1992 Jul 20;141(2):147-50. doi: 10.1016/0304-3940(92)90882-8.
Endothelin (ET) is thought to be involved in the central regulation of body water metabolism. A recent perfusion study of rat hypothalamus showed that ET has a direct stimulatory action on arginine-vasopressin (AVP) release. This study was undertaken to investigate whether ET acts directly on AVP release for supraoptic nucleus (SON) neurons, using brain slices containing only the SON. It was demonstrated that ET inhibited the AVP release dose-dependently from 10(-11) M to 10(-6) M. No difference of the effects of ET-1 and ET-3 on AVP release was observed. These results suggest that ET directly inhibits SON neurons through the ETB receptor.
内皮素（ET）被认为参与机体水代谢的中枢调节。最近一项对大鼠下丘脑的灌注研究表明，ET对精氨酸加压素（AVP）的释放具有直接刺激作用。本研究旨在使用仅包含视上核（SON）的脑片，研究ET是否直接作用于SON神经元的AVP释放。结果表明，ET在10^(-11) M至10^(-6) M浓度范围内剂量依赖性地抑制AVP释放。未观察到ET-1和ET-3对AVP释放的影响有差异。这些结果提示，ET通过ETB受体直接抑制SON神经元。
