Tabatabaei A, Perry T L, Hansen S, Krieger C
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1992 Jul 20;141(2):192-4. doi: 10.1016/0304-3940(92)90892-b.
The protective effect of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced reduction of striatal dopamine (DA) was examined in C57 BL/6 mice. Striatal DA levels were significantly higher in animals receiving parenteral MK-801 before and for 48 h following MPTP administration after 28 days than in animals receiving MPTP alone. The effect was not due to inhibition of monoamine oxidase-B (MAO-B) by MK-801. These data suggest that NMDA receptors may be involved in some of the neurotoxicity produced by MPTP.
在C57 BL/6小鼠中检测了N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的纹状体多巴胺（DA）减少的保护作用。在28天后给予MPTP之前和之后48小时接受肠胃外MK-801的动物，其纹状体DA水平显著高于仅接受MPTP的动物。该作用并非由MK-801对单胺氧化酶-B（MAO-B）的抑制所致。这些数据表明，NMDA受体可能参与了MPTP产生的某些神经毒性作用。
