MK-801对小鼠中脑黑质多巴胺能神经元变性所致纹状体多巴胺减少的部分保护作用。

Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice.

作者信息

Tabatabaei A, Perry T L, Hansen S, Krieger C

机构信息

Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

出版信息

Neurosci Lett. 1992 Jul 20;141(2):192-4. doi: 10.1016/0304-3940(92)90892-b.

DOI:10.1016/0304-3940(92)90892-b

PMID:1436633

Abstract

The protective effect of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced reduction of striatal dopamine (DA) was examined in C57 BL/6 mice. Striatal DA levels were significantly higher in animals receiving parenteral MK-801 before and for 48 h following MPTP administration after 28 days than in animals receiving MPTP alone. The effect was not due to inhibition of monoamine oxidase-B (MAO-B) by MK-801. These data suggest that NMDA receptors may be involved in some of the neurotoxicity produced by MPTP.

摘要

在C57 BL/6小鼠中检测了N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的纹状体多巴胺（DA）减少的保护作用。在28天后给予MPTP之前和之后48小时接受肠胃外MK-801的动物，其纹状体DA水平显著高于仅接受MPTP的动物。该作用并非由MK-801对单胺氧化酶-B（MAO-B）的抑制所致。这些数据表明，NMDA受体可能参与了MPTP产生的某些神经毒性作用。