McTigue D M, Rogers R C, Stephens R L
Department of Physiology, Ohio State University, College of Medicine, Columbus 43210.
Neurosci Lett. 1992 Sep 14;144(1-2):61-4. doi: 10.1016/0304-3940(92)90716-k.
The effects of serotonin (5HT) and a thyrotropin-releasing hormone (TRH) analogue, RX77368, on vagal control of gastric acid secretion were studied. Microinjection of RX77368 (0.66 pmol in 10 nl), but not 5HT (8 pmol in 10 nl), into the dorsal vagal complex (DVC) evoked a significant increase in acid output. When the same doses of RX77368 and 5HT were co-injected, the amount of acid secreted was significantly greater than that due to RX77368 alone. Thus, 5HT and the TRH analogue interact within the DVC to enhance vagal stimulation of acid secretion. The study suggests a possible functional significance of raphe TRH/serotonergic tracts projecting to the DVC.
研究了血清素（5-羟色胺，5HT）和促甲状腺激素释放激素（TRH）类似物RX77368对迷走神经控制胃酸分泌的影响。向迷走神经背侧复合体（DVC）微量注射RX77368（10纳升含0.66皮摩尔）可引起酸分泌显著增加，但注射5HT（10纳升含8皮摩尔）则无此作用。当同时注射相同剂量的RX77368和5HT时，分泌的酸量显著大于单独注射RX77368时。因此，5HT和TRH类似物在DVC内相互作用，增强迷走神经对酸分泌的刺激。该研究提示了中缝核TRH/5-羟色胺能纤维束投射到DVC可能具有的功能意义。
