Spînu I, Ionescu T, Ulmeanu V, Voiculescu M
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1977 Apr-Jun;22(2):87-92.
Biological, sero-epidemiological and bacteriological investigations, carried out in the town of Bucharest for evaluating the present diphtheria vaccination programme showed: -- high anatoxin titers, exceeding the titer considered as protective, in the vaccinates ; -- a concentration of the level of the titers of 1--4 AU/ml, in over 62% of the subjects, which means that the protective titer was exceeded 33 to lucru: -- negative Schick reaction, in the mean 95.06%, in the subjects examined during the 1969--1975 period; -- isolation of the Bacillus diphtheriae in a proportion of 0.08%, none of the toxigenic gravis type. The authors, correlating these data, consider the present vaccination calendar too loaded both as number of inoculations and as antigen concentration per revaccination dose, and recommend reconsideration of the vaccination programme.
在布加勒斯特市开展的旨在评估当前白喉疫苗接种计划的生物学、血清流行病学和细菌学调查显示：——接种疫苗者体内抗毒素滴度较高，超过了被视为具有保护作用的滴度；——超过62%的受试者抗毒素滴度集中在1至4 AU/ml水平，这意味着保护滴度被超过了33至lucru（此处“lucru”可能有误，未明确准确含义）；——在1969 - 1975年期间接受检查的受试者中，平均95.06%的人锡克试验呈阴性；——白喉杆菌的分离率为0.08%，且均非产毒严重型。作者将这些数据相互关联后，认为当前的疫苗接种日程在接种次数以及每次复种剂量的抗原浓度方面都过于繁重，并建议重新考虑疫苗接种计划。
