Pingitore R, Bonucci M, Bigini D, Ciancia E M, Vignati S
Istituto e museo di anatomia e istologia patologica Università di Pisa.
Pathologica. 1992 Mar-Apr;84(1090):171-85.
The morphological analysis of 223 cases of chronic calculous cholecystitis has drawn attention to the following outstanding facts: (a) elementary lesions are numerous (above all ulceration, mucosal erosion, antral and intestinal metaplasia) and put together a complex sight; (b) mild, moderate and severe dysplasias have a surprising high incidence (67%), even in the age-group under 40; (c) dysplasia is more common in the gallbladders bearing parallel hyperplastic and metaplastic mucosal changes, if compared with gallbladders where these changes are lacking; (d) thickness of gallbladder's wall and incidence of dysplasia are in direct relation; (e) echographic preoperative assessment of wall's thickness has predictive value for presence of dysplasia; (f) CEA and CA 19-9 have a progressively increasing expression in the various degrees of dysplasia.
对223例慢性结石性胆囊炎的形态学分析揭示了以下突出事实：(a)基本病变众多（尤其是溃疡、黏膜糜烂、胃窦化生和肠化生），构成了一幅复杂的景象；(b)轻度、中度和重度发育异常的发生率惊人地高（67%），即使在40岁以下的年龄组中也是如此；(c)与没有这些变化的胆囊相比，伴有平行增生和化生黏膜变化的胆囊中发育异常更为常见；(d)胆囊壁厚度与发育异常发生率呈直接关系；(e)术前超声对胆囊壁厚度的评估对发育异常的存在具有预测价值；(f)癌胚抗原（CEA）和糖类抗原19-9（CA 19-9）在不同程度的发育异常中表达逐渐增加。
