Potworowski E, Bischoff P, Oth D
Centre de Recherche en Immunologie, Institut Armand-Frappier, Laval, Qc., Canada.
Nutr Cancer. 1992;17(3):217-21. doi: 10.1080/01635589209514190.
C57BL/Ka mice were fed diets rich in omega 3 or omega 6 polyunsaturated fatty acids and inoculated with the thymic lymphoma-inducing retrovirus RadLV. Mice receiving the omega 3 diet died significantly sooner than those receiving the omega 6 diet. Of the three known mechanisms by which fatty acids can exert antiviral activity, namely, modification of membrane fluidity, modulation of immune response, and synthesis of metabolites with antiviral activity, the first two can be eliminated in the model under study. It is therefore concluded that differences in survival are due to fatty acid metabolites with distinct antiviral activities.
给C57BL/Ka小鼠喂食富含ω-3或ω-6多不饱和脂肪酸的饮食，并接种诱导胸腺淋巴瘤的逆转录病毒RadLV。摄入ω-3饮食的小鼠死亡时间明显早于摄入ω-6饮食的小鼠。脂肪酸发挥抗病毒活性的三种已知机制，即膜流动性的改变、免疫反应的调节以及具有抗病毒活性的代谢产物的合成，在前两种机制在本研究模型中可以排除。因此得出结论，生存差异是由于具有不同抗病毒活性的脂肪酸代谢产物所致。
