Smith L H, VanGulick A J
Riverside Methodist Hospitals, Columbus, OH.
Oncol Nurs Forum. 1992 Oct;19(9):1337-42.
Neutropenic enterocolitis is a life-threatening condition often seen in patients experiencing prolonged periods of neutropenia from conditions such as leukemia and lymphoma and from aggressive chemotherapy regimens. Its exact pathologic process remains unclear; however, it has been proposed that direct cytotoxic damage occurs to the bowel mucosa with subsequent microbial invasion complicated by the lack of adequate neutrophil response. The damage may progress to bowel perforation and septic shock. Early recognition and management by healthcare team members are crucial for the improved prognosis of these individuals. Controversy continues to exist concerning management options and the timing of these interventions. This article outlines nursing and medical management of the patient with neutropenic enterocolitis.
中性粒细胞减少性小肠结肠炎是一种危及生命的疾病，常见于因白血病、淋巴瘤等疾病以及积极的化疗方案导致长期中性粒细胞减少的患者。其确切的病理过程尚不清楚；然而，有人提出，肠道黏膜会发生直接的细胞毒性损伤，随后由于缺乏足够的中性粒细胞反应而并发微生物入侵。这种损伤可能会发展为肠穿孔和感染性休克。医疗团队成员的早期识别和管理对于改善这些患者的预后至关重要。关于管理方案和这些干预措施的时机仍存在争议。本文概述了中性粒细胞减少性小肠结肠炎患者的护理和医疗管理。
