Norrdin R W, Bordier P, Miller C W
Virchows Arch A Pathol Anat Histol. 1977 Sep 28;375(3):169-83. doi: 10.1007/BF01102986.
A morphometric study was performed on undecalcified sections of trabecular bone from the ribs of adult dogs that were controls (n = 8), or had various degrees of renal failure as a result of perinatal irradiation (n = 16). In a group identified as markedly uremic there was an increase in the proportion of surface with osteoid seams (P less than 0.01), osteoblasts (P less than 0.01) and osteoclastic resorption (P less than 0.01) as well as the % osteoid volume (P less than 0.01). Aside from a decrease in the % trabecular bone which was of unclear significance, the results agree well with those of similar studies in man. Within this group, 6 of the samples had a histologic pattern that was principally that of hyperarathyroidism and in the remaining 2 there was evidence of a mineralization defect and osteomalacic changes. These 2 dogs had the poorest renal function and one that had been biopsied 5 months earlier, when its renal function was less impaired, had had a hyperparathyroid pattern.
对成年犬肋骨小梁骨的未脱钙切片进行了形态计量学研究，这些成年犬作为对照（n = 8），或因围产期辐射而患有不同程度的肾衰竭（n = 16）。在一组被确定为明显尿毒症的犬中，类骨质缝表面比例（P < 0.01）、成骨细胞（P < 0.01）、破骨细胞吸收（P < 0.01）以及类骨质体积百分比（P < 0.01）均增加。除了小梁骨百分比降低（其意义尚不清楚）外，结果与人类类似研究的结果非常吻合。在该组中，6个样本的组织学模式主要为甲状旁腺功能亢进，其余2个样本有矿化缺陷和骨软化改变的证据。这2只犬的肾功能最差，其中1只在5个月前进行活检时肾功能受损较轻，当时其组织学模式为甲状旁腺功能亢进。
