Urasiński T, Peregud-Pogorzelski J, Bartoszewicz L
I Kliniki Pediatrii Instytutu Pediatrii PAM Szczecinie.
Pol Tyg Lek. 1992;47(16-17):360-2.
Relationship between the result of therapy in 48 cases of the acute lymphoblastic leukemia in childhood and character of response to corticosteroids, classified according to BMF group, has been assessed. Follow up period ranged from 13 to 75 months (mean 36 months, median 39 months). In was found, that the probability of survival free from any events, probability of complete remission persistence, and probability of survival after diagnosis have been statistically significantly higher in the group of patients with positive response to corticosteroids in comparison with patients non-responding to these agents. However, there was no significant difference in the number of recurrencies with the involvement of CNS. Authors share the opinion that their results confirm an opinion of Riehm et al. that the response to corticosteroids is of prognostic value in the acute lymphoblastic leukemia in childhood.
评估了48例儿童急性淋巴细胞白血病的治疗结果与根据BMF组分类的对皮质类固醇反应特征之间的关系。随访期为13至75个月（平均36个月，中位数39个月）。结果发现，与对这些药物无反应的患者相比，对皮质类固醇有阳性反应的患者组中无任何事件生存的概率、完全缓解持续的概率以及诊断后生存的概率在统计学上显著更高。然而，中枢神经系统受累的复发次数没有显著差异。作者们一致认为，他们的结果证实了里姆等人的观点，即对皮质类固醇的反应在儿童急性淋巴细胞白血病中具有预后价值。
