Shelnutt S, Hudzik T J, Lattin D L, McMillan D E
Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205.
Pharmacol Biochem Behav. 1992 Oct;43(2):509-11. doi: 10.1016/0091-3057(92)90185-i.
The effects of cocaine and benzoylecognine ethyl ester (ethylcocaine), its metabolite found only in simultaneous users of cocaine and ethanol, were studied in rats responding for food under a multiple fixed-ratio fixed-interval schedule of food presentation. Both cocaine and ethylcocaine increased rates of responding under the fixed-interval component and decreased the quarter life. Both drugs only decreased rates of responding under the fixed-ratio component. Cocaine was approximately equipotent to ethylcocaine. Ethylcocaine may contribute to interactions between cocaine and ethanol by exerting cocaine-like effects not seen with other cocaine metabolites.
在以多次固定比率-固定间隔食物呈现模式获取食物的大鼠中，研究了可卡因及其代谢物苯甲酰爱康宁乙酯（乙基可卡因，仅在同时使用可卡因和乙醇的使用者体内发现）的作用。可卡因和乙基可卡因均提高了固定间隔部分的反应率，并缩短了四分位寿命。两种药物仅降低了固定比率部分的反应率。可卡因与乙基可卡因的效力大致相当。乙基可卡因可能通过发挥其他可卡因代谢物未见的类似可卡因的作用，促成可卡因与乙醇之间的相互作用。
