Pernak J, Krysiński J, Skrzypczak A
Institut für Chemische Technologie, Technischen Universität, Poznań, Polen.
Pharmazie. 1992 Aug;47(8):623-6.
The synthesis of quaternary imidazolium compounds was performed by reaction of 1-ethyl- or 1-n-dodecyl-2-phenylimidazole with chloromethyl-n-alkyl ether or chloromethyl-n-alkyl sulfid. The antibacterial properties of the compounds obtained were tested on 13 strains of bacteria and fungi. 1-Ethyl-2-phenyl-3-(n-decylthiomethyl)-, 1-ethyl-2-phenyl-3-(n-dodecylthiomethyl)imidazolium chloride and 1-n-dodecyl-2-phenyl-3-(n-butylthiomethyl)-, 1-n-dodecyl-2-phenyl-3-(n-hexylthiomethyl)imidazolium chloride indicated the best antibacterial activity.
通过使1-乙基-或1-正十二烷基-2-苯基咪唑与氯甲基-n-烷基醚或氯甲基-n-烷基硫化物反应来进行季铵化咪唑鎓化合物的合成。对所制得化合物的抗菌性能在13种细菌和真菌菌株上进行了测试。1-乙基-2-苯基-3-(正癸基硫甲基)-、1-乙基-2-苯基-3-(正十二烷基硫甲基)氯化咪唑鎓以及1-正十二烷基-2-苯基-3-(正丁基硫甲基)-、1-正十二烷基-2-苯基-3-(正己基硫甲基)氯化咪唑鎓显示出最佳的抗菌活性。