[1-正己基-2-苯基-3-(正烷氧基甲基)-和1-正己基-2-苯基-3-(6-正烷基硫甲基)氯化咪唑鎓的合成与作用]
[Synthesis and action of 1-n-hexyl-2-phenyl-3-(n-alkoxymethyl)- and 1-n-hexyl-2-phenyl-3-(6-n-alkylthiomethyl)imidazolium chlorides].
作者信息
Pernak J, Skrzypczak A, Michalak L, Krysiński J, Peterko B
机构信息
Institut für Chemische Technologie, Technischen Universität, Poznań, Polen.
出版信息
Pharmazie. 1990 Sep;45(9):688-9.
PMID:2284316
Abstract
The synthesis of quaternary imidazolium chlorides was performed by reaction of 1-n-hexyl-2-phenyl-imidazole with chloromethylalkyl ether or chlormethylalkyl sulfide. The antibacterial properties of the compounds obtained was tested on 13 strains of bacteria and fungi. Chlorides with octyl- and decylthiomethyl moiety indicated the best antibacterial activity.
摘要
通过1-正己基-2-苯基咪唑与氯甲基烷基醚或氯甲基烷基硫醚反应合成了季铵化咪唑氯化物。对所得化合物的抗菌性能在13种细菌和真菌菌株上进行了测试。带有辛基和癸基硫甲基部分的氯化物显示出最佳的抗菌活性。
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