Joffe R T, Levitt A J
Mood Disorders Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
Psychoneuroendocrinology. 1992 May-Jul;17(2-3):215-21. doi: 10.1016/0306-4530(92)90060-k.
Subclinical hypothyroidism (SCH) has been reported to occur in patients with a variety of affective syndromes. However, the clinical correlates of SCH in patients with major depression have received limited attention. We therefore examined demographic, clinical and treatment response variables in a cohort of patients with unipolar, nonpsychotic major depression with and without SCH. Of 139 subjects, 19 had SCH defined as an elevated basal TSH with normal circulating levels of T3 and T4. Major depression with SCH differed from that without SCH by the presence of a concurrent panic disorder and a poorer antidepressant response.
据报道，亚临床甲状腺功能减退症（SCH）在患有各种情感综合征的患者中都会出现。然而，重度抑郁症患者中SCH的临床相关性受到的关注有限。因此，我们在一组患有单相、非精神病性重度抑郁症且伴有或不伴有SCH的患者中，研究了人口统计学、临床和治疗反应变量。在139名受试者中，19名患有SCH，其定义为基础促甲状腺激素（TSH）升高，而三碘甲状腺原氨酸（T3）和甲状腺素（T4）的循环水平正常。伴有SCH的重度抑郁症与不伴有SCH的重度抑郁症的不同之处在于，前者同时存在惊恐障碍且抗抑郁反应较差。
