Schaefer S, van Tyen R, Saloner D
Department of Cardiology, Veterans Affairs Medical Center, San Francisco.
Radiology. 1992 Dec;185(3):795-801. doi: 10.1148/radiology.185.3.1438765.
To determine whether myocardial perfusion abnormalities could be detected in patients with coronary artery disease by means of contrast material-enhanced magnetic resonance (MR) images, a snapshot imaging technique was used in six patients with coronary artery disease and four healthy subjects in conjunction with pharmacologic stress (dipyridamole infusion) and bolus injection of gadopentetate dimeglumine. MR images from all patients and healthy subjects were quantitatively analyzed to define spatial changes in signal intensity after administration of dipyridamole and gadopentetate dimeglumine. The resultant findings were compared with findings on thallium-201 scintigrams obtained after administration of dipyridamole and on coronary arteriograms in all patients. Nine myocardial regions supplied by stenosed arteries showed diminished levels of signal intensity after infusion of the contrast agent compared with those of normally perfused regions. These findings were in agreement with those obtained with T1-201 scintigraphy (in eight of nine regions) and arteriography. Thus, contrast-enhanced high-speed MR imaging with use of dipyridamole enabled detection of regional perfusion abnormalities in humans.
为了确定能否通过对比剂增强磁共振（MR）成像在冠心病患者中检测到心肌灌注异常，对6例冠心病患者和4名健康受试者采用了一种快照成像技术，同时结合药物负荷试验（静脉输注双嘧达莫）和推注钆喷酸葡胺。对所有患者和健康受试者的MR图像进行定量分析，以确定静脉输注双嘧达莫和钆喷酸葡胺后信号强度的空间变化。将所得结果与所有患者在静脉输注双嘧达莫后获得的铊-201闪烁扫描结果以及冠状动脉造影结果进行比较。与正常灌注区域相比，9个由狭窄动脉供血的心肌区域在注入对比剂后信号强度水平降低。这些结果与铊-201闪烁扫描（9个区域中的8个）和血管造影结果一致。因此，使用双嘧达莫的对比增强高速MR成像能够检测出人类的局部灌注异常。
