Bhansali K G, Eugere E J
College of Pharmacy and Health Sciences, Texas Southern University, Houston 77004.
Res Commun Chem Pathol Pharmacol. 1992 Aug;77(2):161-9.
During pregnancy the placenta is both the source and target for the actions of steroid hormones. In fact, an intact feto-placental unit is capable of elaborating increasing levels of a wide variety of steroid hormones and many other substances. The falling levels of steroid hormones, like estrogens and progesterone in serum and urine have been reported during pregnancy induced hypertension and/or preeclampsia. The purpose of this study was to determine the concentration of 17 beta-estradiol and progesterone in cytosol, nucleic fraction and particulate fraction of term placentae of normal and hypertensive patients by radioimmunoassay. Data from this study reveal the concentrations of 17 beta-estradiol (E2) and progesterone (P) in various cellular fractions from six placentae of normal patients (NP) and five placentae of hypertensive patients (HP). In HP overall concentrations of E2 (75.8 ng/gm) and P(46.5 micrograms/gm) is greater than those in NP, 32.6 ng/gm and 25.0 micrograms/gm respectively. The concentration of E2 in nuclear fraction of NP and HP remains unchanged while P concentration of nuclear fraction of HP (25.4 micrograms/gm) is much greater than those of NP (8.8 micrograms/gm). Moreover, the E2 concentration (55.5 ng/gm) in cytosol of HP is much greater than those of NP (12.3 ng/gm). Therefore, this study indicates that the abnormal concentrations of E2 and P of placentae are associated with pregnancy induced hypertension.
在孕期，胎盘既是甾体激素作用的来源，也是其作用的靶点。事实上，完整的胎儿 - 胎盘单位能够合成越来越多的多种甾体激素及许多其他物质。据报道，在妊娠高血压和/或先兆子痫期间，血清和尿液中的甾体激素如雌激素和孕酮水平会下降。本研究的目的是通过放射免疫分析法测定正常和高血压患者足月胎盘的细胞溶质、核酸部分和微粒部分中17β - 雌二醇和孕酮的浓度。本研究的数据揭示了来自六例正常患者（NP）胎盘和五例高血压患者（HP）胎盘的各种细胞部分中17β - 雌二醇（E2）和孕酮（P）的浓度。在高血压患者中，E2的总体浓度（75.8 ng/gm）和P的总体浓度（46.5微克/gm）分别高于正常患者，正常患者中E2和P的总体浓度分别为32.6 ng/gm和25.0微克/gm。正常患者和高血压患者胎盘核部分中E2的浓度保持不变，而高血压患者胎盘核部分中P的浓度（25.4微克/gm）远高于正常患者（8.8微克/gm）。此外，高血压患者胎盘细胞溶质中E2的浓度（55.5 ng/gm）远高于正常患者（12.3 ng/gm）。因此，本研究表明胎盘E2和P的异常浓度与妊娠高血压有关。
