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颞叶癫痫的外科治疗

Surgical therapy of temporal lobe seizures.

作者信息

Liu Z, Tian Z, Kang G, Cheng L, Li S, Chen X, Fin H, Zui S

机构信息

Department of Neurosurgery, Navy General Hospital of PLA, Beijing, China.

出版信息

Stereotact Funct Neurosurg. 1992;58(1-4):194-9.

PMID:1439340
Abstract

Resection of epileptogenic lesions and pathological studies were performed in all 35 patients with temporal lobe epilepsy, 20 male and 15 female. Their ages ranged from 6 to 48 years with an average of 22 years. Various examinations including CT scan were carried out without any positive finding. EEG showed spike formation in the temporal lobes in all 35 patients. Epilepsy lesions were removed from the right temporal lobe in 22 patients and from the left temporal lobe in 13 patients. Pathological changes were found in all epilepsy lesions by light and electron microscopy. The operative outcomes were seizure-free since discharge in 10 patients (28.5%), seizure-free after some early attacks (34.2%) in 12 patients, seizure-free for 2 or more years and then rare or occasional attacks in 6 patients (17.1%), marked reduction of seizures in 5 patients (14.5%) and moderate or less reduction of seizure tendency in 2 patients (5.7%), with an effective rate of 93%. No death or severe complications did occur.

摘要

对35例颞叶癫痫患者进行了致痫灶切除及病理研究,其中男性20例,女性15例。年龄范围为6至48岁,平均22岁。进行了包括CT扫描在内的各项检查,均未发现阳性结果。35例患者脑电图均显示颞叶有棘波形成。22例患者的癫痫病灶取自右侧颞叶,13例患者的病灶取自左侧颞叶。通过光镜和电镜在所有癫痫病灶中均发现了病理变化。手术结果为:10例患者(28.5%)出院后无癫痫发作;12例患者(34.2%)在早期发作几次后无癫痫发作;6例患者(17.1%)无癫痫发作2年或更长时间,之后很少或偶尔发作;5例患者(14.5%)癫痫发作明显减少;2例患者(5.7%)癫痫发作趋势中度或轻度减轻,有效率为93%。未发生死亡或严重并发症。

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