Goldman M S, Kelly P J
Department of Neurosurgery, Mayo Clinic, Rochester, Minn.
Stereotact Funct Neurosurg. 1992;58(1-4):22-5. doi: 10.1159/000098966.
Objective surgical symptomatic outcome of ventrolateral (VL) thalamotomy specifically for essential tremor is uncommonly reported and functional outcome has not been investigated previously. In the present series, 7 patients underwent unilateral and 1 patient staged bilateral VL thalamotomies for disabling medically refractory essential tremor. At follow-up examination (mean 17.3 months, range 1-50 months), all patients enjoyed complete ablation or significant amelioration of the targeted tremor. Disability as determined by a modified form of an established rating scale for tremor was reduced from moderate (57%) or severe (43%) to absent (86%) or mild (14%). Interestingly, voice tremor was ablated or significantly improved in 71.4% of patients with preoperative voice tremor.
腹外侧丘脑切开术治疗特发性震颤的手术症状性结果鲜见报道，且此前尚未对其功能结果进行研究。在本系列研究中，7例患者接受了单侧腹外侧丘脑切开术，1例患者分阶段接受了双侧腹外侧丘脑切开术，以治疗难治性致残性特发性震颤。在随访检查时（平均17.3个月，范围1 - 50个月），所有患者的目标震颤均完全消除或显著改善。根据一种改良的既定震颤评定量表确定的残疾程度从中度（57%）或重度（43%）降至无残疾（86%）或轻度（14%）。有趣的是，术前有声音震颤的患者中，71.4%的患者声音震颤消除或显著改善。
