Svensson B G, Schütz A, Nilsson A, Akesson I, Akesson B, Skerfving S
Department of Occupational and Environmental Medicine, University Hospital, University of Lund, Sweden.
Sci Total Environ. 1992 Sep 11;126(1-2):61-74. doi: 10.1016/0048-9697(92)90484-a.
In a total of 395 subjects with varying fish consumption habits, mercury levels in whole blood (B-Hg), and selenium levels in plasma (P-Se) were studied. Also, in subcohorts, mercury levels in blood cells (Ery-Hg; n = 79), plasma (P-Hg; n = 158) and urine (U-Hg; n = 125) were analysed. There were statistically significant associations between fish intake on the one hand, and B-Hg, Ery-Hg and P-Hg, on the other, but not so with U-Hg. In subjects who never had fish, the average B-Hg was 1.8 ng/g, in subjects who had at least two fish meals each week, 6.7 ng/g. Ery-Hg, and to a less extent P-Hg, were associated with levels of marine n-3 polyunsaturated fatty acids (PUFA) in serum phosphatidylcholine. P-Hg and U-Hg were associated with numbers of teeth with amalgam fillings. P-Se also correlated with fish intake. In subjects who never had fish, P-Se averaged 80 micrograms/l, in subjects who had at least two fish meals per week, 91 micrograms/l. There was an association between PUFA and P-Se. Further, there were statistically significant associations between P-Se on the one hand, and B-Hg, Ery-Hg and P-Hg on the other. The data clearly demonstrate the importance of fish for the exposure to methylmercury and selenium in the Swedish diet, and the impact of amalgam as a source of exposure to inorganic mercury.
在总共395名具有不同鱼类消费习惯的受试者中，研究了全血汞水平（B-Hg）和血浆硒水平（P-Se）。此外，在亚队列中，分析了血细胞汞水平（Ery-Hg；n = 79）、血浆汞水平（P-Hg；n = 158）和尿液汞水平（U-Hg；n = 125）。一方面，鱼类摄入量与B-Hg、Ery-Hg和P-Hg之间存在统计学上的显著关联，但与U-Hg无关。在从未食用过鱼类的受试者中，平均B-Hg为1.8 ng/g，在每周至少食用两餐鱼的受试者中，为6.7 ng/g。Ery-Hg以及在较小程度上P-Hg与血清磷脂酰胆碱中海洋n-3多不饱和脂肪酸（PUFA）的水平相关。P-Hg和U-Hg与有汞合金填充物的牙齿数量相关。P-Se也与鱼类摄入量相关。在从未食用过鱼类的受试者中，P-Se平均为80微克/升，在每周至少食用两餐鱼的受试者中，为91微克/升。PUFA与P-Se之间存在关联。此外，一方面P-Se与B-Hg、Ery-Hg和P-Hg之间存在统计学上的显著关联。数据清楚地表明了鱼类在瑞典饮食中对于甲基汞和硒暴露的重要性，以及汞合金作为无机汞暴露源的影响。
