Creutz C E
Department of Pharmacology, University of Virginia, Charlottesville 22908.
Science. 1992 Nov 6;258(5084):924-31. doi: 10.1126/science.1439804.
The annexins are a group of homologous proteins that bind phospholipids in the presence of calcium. They may provide a major pathway for communication between cellular membranes and their cytoplasmic environment. Annexins have a characteristic "bivalent" activity in the sense that they can draw two membranes together when activated by calcium. This has led to the hypothesis that certain members of this protein family may initiate contact and fusion between a secretory vesicle membrane and the plasma membrane during the process of exocytosis.
膜联蛋白是一组在钙离子存在下能结合磷脂的同源蛋白。它们可能为细胞膜与其细胞质环境之间的通讯提供一条主要途径。膜联蛋白具有一种特征性的“二价”活性，即当被钙离子激活时，它们能将两个膜拉近。这就引发了一种假说，即该蛋白家族的某些成员可能在胞吐作用过程中启动分泌小泡膜与质膜之间的接触和融合。
