Kurniawan A, Sartono E, Setiowati W E, Supali T, Wibowo H, Rukmono B, Partono F
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta.
Southeast Asian J Trop Med Public Health. 1992 Jun;23(2):288-92.
Clinical trials of Ivermectin in single oral doses of 200, 400, and 1,000 mg/kg body weight or in multiple doses of 200 mg/kg body weight for 5 consecutive days were performed in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani. Optimal microfilaricidal effect occurred at 200 mg/kg body weight. The drug was less effective than diethylcarbamazine in this animal model for human filariasis but had no adverse effects.
对感染卡里曼丹吴策线虫的叶猴进行了伊维菌素临床试验，单剂量口服分别为200、400和1000毫克/千克体重，或连续5天多剂量口服200毫克/千克体重。200毫克/千克体重时出现最佳杀微丝蚴效果。在这个人类丝虫病动物模型中，该药物的效果不如乙胺嗪，但没有不良反应。
