Martinez-Hernandez A, Bell K P, Norenberg M D
Science. 1977 Mar 25;195(4284):1356-8. doi: 10.1126/science.14400.
Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.
运用光学显微镜免疫组织化学技术检测谷氨酰胺合成酶在大鼠脑内的分布。结果发现谷氨酰胺合成酶定位于神经胶质细胞。神经元细胞体、内皮细胞和脉络丛上皮均未检测到该酶。这些发现表明，神经胶质细胞在脑内谷氨酸、γ-氨基丁酸和氨的代谢中起关键作用。
