HARWOOD R F, AREEKUL S
Science. 1960 May 6;131(3410):1369-70. doi: 10.1126/science.131.3410.1369.
Toxicants in purified form can be identified by applying a base dose, consisting of the amount causing 50-percent mortality in one organism, to other susceptible organisms. This yields a mortality pattern which "fingerprints" the compound. Toxicants related by chemical structure or biological activity tend to possess similar mortality patterns.