Heynen C, Luisetto G, Cecchettin M, Kanis J A, Brassine A, Gaspar S, Franchimont P
C R Seances Soc Biol Fil. 1977;171(3):690-5.
In spite of an important metabolic role of the liver in the synthesis and degradation of hormonal peptides and seco-steroïds, the clinical occurrence of disturbed regulation of calcium and phosphorus metabolism is rare in hepatic disorders. 23 patients suffering from alcoholic cirrhosis were studied. All had normal plasma calcium and phosphorus concentration as well as immunoreactive parathyroid hormone levels. 25 hydroxyvitamin D3 levels were decreased. Immunoreactive calcitonin were increased in relation to the increase in plasma alkaline phosphatase activity. The causes and consequences of these endocrine disturbances are discussed.
尽管肝脏在激素肽和甾体激素的合成与降解中具有重要的代谢作用,但钙磷代谢调节紊乱在肝脏疾病中的临床发生率却很低。对23例酒精性肝硬化患者进行了研究。所有患者的血浆钙、磷浓度以及免疫反应性甲状旁腺激素水平均正常。25羟维生素D3水平降低。免疫反应性降钙素随血浆碱性磷酸酶活性的升高而增加。本文讨论了这些内分泌紊乱的原因和后果。