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[早期胃癌的诊断难点与失误]

[Diagnostic difficulties and errors in early stomach cancer].

作者信息

Ivashkin V T, Kalinin A V

出版信息

Ter Arkh. 1992;64(4):89-94.

PMID:1440319
Abstract

Difficulties that occur in the diagnosis of early gastric carcinoma (EGC) were studied on a material of 1617 prophylactic endoscopic examinations of persons who did not make any complaints of the alimentary organs and 2158 primary gastroscopies performed in accordance with the patients' complaints, results of the dispensary follow-up of 811 patients who made up a risk group, and an analysis of case reports of 183 patients in whom EGC was confirmed by surgery. The authors emphasize a high percentage of errors determined by the lack of the pathognomonic symptomatology, difficulties of interpreting the endoscopic appearance and histologic confirmation of carcinoma. To improve early diagnosis of gastric carcinoma (GC), it is recommended that every endoscopic investigation be performed with oncological apprehension, paying attention even to the minimum focal changes in the gastric mucosa and making spot biopsy of those changes. It is also advisable that a more strict approach should be exercised to the formation of risk groups, restricting them to the patients at greater risk for GC or with unrecognized GC (first revealed and poorly healing ulcers, polyps measuring over 2 cm in diameter, grade III dysplasia discovered in gastric biopsy specimens). Such patients should be placed under dispensary observation including endoscopy which is to be made in the first stage after 1, 3 and 6 months.

摘要

对1617例无消化道器官不适者进行的预防性内镜检查、2158例根据患者主诉进行的初次胃镜检查、811例高危组患者的门诊随访结果以及183例经手术确诊为早期胃癌(EGC)患者的病例报告进行研究,分析早期胃癌诊断中出现的困难。作者强调,由于缺乏特征性症状、内镜表现解读困难以及癌组织学确诊困难,误诊率较高。为提高胃癌(GC)的早期诊断率,建议每次内镜检查时都要有肿瘤学意识,即使注意胃黏膜的最小局灶性变化并对这些变化进行定点活检。对于高危组的形成也应采取更严格的方法,将其限制在胃癌风险较高或未识别出胃癌的患者(首次发现且愈合不良的溃疡、直径超过2 cm的息肉、胃活检标本中发现的III级发育异常)。此类患者应接受门诊观察,包括在内镜检查,在第1、3和6个月的第一阶段进行。

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