挪威白种人和日本人中DPA1与DPB1等位基因之间的连锁不平衡

Linkage disequilibrium between DPA1 and DPB1 alleles among Norwegian Caucasoids and Japanese.

作者信息

Spurkland A, Vartdal F

机构信息

Institute of Transplantation, Immunology, National Hospital, Oslo, Norway.

出版信息

Tissue Antigens. 1992 Jul;40(1):1-4. doi: 10.1111/j.1399-0039.1992.tb01950.x.

DOI:10.1111/j.1399-0039.1992.tb01950.x

PMID:1440558

Abstract

Associations between alleles at the DPA1 and DPB1 loci were analyzed in 181 Norwegian caucasoids. Associations were observed between the DPA10201 and the DPB10101, 0901, 1001 and 1101 alleles. An association between DPA10201 and the DPB10901 allele was also observed among 23 healthy Japanese and 24 Japanese MS patients. In addition, it appeared that among Japanese the DPA10201 allele may be associated to the DPB1*0501. In conclusion, alleles at the DPA1 and DPB1 loci display different associations among Norwegian caucasoids and Japanese.

摘要

在181名挪威白种人中分析了DPA1和DPB1基因座上等位基因之间的关联。观察到DPA10201与DPB10101、0901、1001和1101等位基因之间存在关联。在23名健康日本人和24名日本多发性硬化症患者中也观察到DPA10201与DPB10901等位基因之间存在关联。此外，在日本人中，DPA10201等位基因似乎可能与DPB1*0501相关。总之，DPA1和DPB1基因座上的等位基因在挪威白种人和日本人中表现出不同的关联。