Zukin V D
Tsitol Genet. 1992 Jul-Aug;26(4):59-61.
112 mentally weak persons aged from 2 to 18 with different degree of oligophrenia have been examined. Cultivation of blood lymphocytes was performed on medium 199 containing 5% of cattle serum. 9 persons with "fragile" X-chromosome are revealed. High frequency of autosomes fragility among the examined contingent of patients is found. A supposition is advanced on interrelation between homozygosity of "fragile" parts of autosomes and oligophrenia.
对112名年龄在2至18岁之间、患有不同程度智力低下的智力薄弱者进行了检查。在含有5%牛血清的199培养基上进行血液淋巴细胞培养。发现9名患有“脆性”X染色体的患者。在所检查的患者群体中发现常染色体脆性的高频率。提出了常染色体“脆性”部分的纯合性与智力低下之间相互关系的假设。
