KIRPEKAR S M, LEWIS J J
Br J Pharmacol Chemother. 1960 Mar;15(1):175-80. doi: 10.1111/j.1476-5381.1960.tb01228.x.
The effects of reserpine, chlorpromazine and sodium salicylate on oxidative phosphorylation, stimulation of glutamic acid oxidation and adenosinetriphosphatase activity have been compared in vitro with those of 2,4-dinitrophenol using rat liver preparations. All three drugs inhibit oxidative phosphorylation, slightly stimulate glutamic acid oxidation and stimulate adenosinetriphosphatase activity at high concentrations. Reserpine has no effect on adenosinetriphosphatase activity. It is suggested that the characteristic depressant effects of reserpine on isolated tissues in vitro may be due to interference with production of energy by oxidative phosphorylation.
使用大鼠肝脏制剂，在体外比较了利血平、氯丙嗪和水杨酸钠对氧化磷酸化、谷氨酸氧化刺激和三磷酸腺苷酶活性的影响与2,4-二硝基苯酚的影响。所有这三种药物均抑制氧化磷酸化，在高浓度时轻微刺激谷氨酸氧化并刺激三磷酸腺苷酶活性。利血平对三磷酸腺苷酶活性无影响。有人提出，利血平在体外对离体组织的特征性抑制作用可能是由于干扰了氧化磷酸化产生能量的过程。
