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关于二烷基氟化物对母鸡造成脱髓鞘作用的一则笔记。

A note on the demyelination produced in hens by dialkylfluoridates.

作者信息

LANCASTER M C

出版信息

Br J Pharmacol Chemother. 1960 Jun;15(2):279-81. doi: 10.1111/j.1476-5381.1960.tb01244.x.

DOI:10.1111/j.1476-5381.1960.tb01244.x
PMID:14413744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1481926/
Abstract

Hens were treated with organophosphorus compounds until signs of neurotoxicity developed. The sciatic nerves, spinal cord, and medulla were then examined histologically by the Marchi method, to determine the extent and distribution of demyelination. The lesions were proportional to the dose of compound injected, and the spinal cord was more sensitive than the sciatic nerves. It is suggested that the spinal cord, and not the sciatic nerves, is the main site of damage in clinical paralysis following dyflos poisoning.

摘要

用有机磷化合物处理母鸡，直至出现神经毒性迹象。然后采用马尔基氏法对坐骨神经、脊髓和延髓进行组织学检查，以确定脱髓鞘的程度和分布。病变程度与注射化合物的剂量成正比，脊髓比坐骨神经更敏感。研究表明，在敌百虫中毒后的临床麻痹中，主要损伤部位是脊髓而非坐骨神经。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c68f/1481926/cce0711684e1/bripharmchem00053-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c68f/1481926/cce0711684e1/bripharmchem00053-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c68f/1481926/cce0711684e1/bripharmchem00053-0076-a.jpg

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2
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3
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本文引用的文献

1
The relationship between the chemical structure and neurotoxicity of alkyl organophosphorus compounds.烷基有机磷化合物的化学结构与神经毒性之间的关系。
Br J Pharmacol Chemother. 1960 Jun;15(2):271-8. doi: 10.1111/j.1476-5381.1960.tb01243.x.
2
Histochemical mechanisms of the Marchi reaction for degenerating myelin.用于变性髓鞘的马尔基反应的组织化学机制。
J Neurochem. 1958;2(2-3):178-86. doi: 10.1111/j.1471-4159.1958.tb12362.x.
3
The nature of the paralysis in chickens following organo-phosphorus poisoning.
磷酸三邻甲苯酯的环状磷酸盐代谢产物所致鸡神经毒性综合征——一项临床与病理学研究
Br J Pharmacol Chemother. 1962 Jun;18(3):465-74. doi: 10.1111/j.1476-5381.1962.tb01168.x.
4
Comparison of the functional effects of dyflos, tri-o-cresyl phosphate and tri-p-ethylphenyl phosphate in chickens.敌百虫、磷酸三甲苯酯和磷酸三对乙苯基酯对鸡的功能影响比较。
Br J Pharmacol Chemother. 1961 Aug;17(1):21-7. doi: 10.1111/j.1476-5381.1961.tb01100.x.
5
Further observations on the response of the peripheral and central nervous system of the rabbit to sodium diethyldithiocarbamate.关于兔的外周和中枢神经系统对二乙基二硫代氨基甲酸钠反应的进一步观察
Acta Neuropathol. 1973 Apr 18;24(2):161-73. doi: 10.1007/BF00684837.
J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):181-9. doi: 10.1002/path.1700690124.
4
The toxic effects of triortho-cresyl phosphate on the nervous system; an experimental study in hens.磷酸三甲苯酯对神经系统的毒性作用；母鸡的实验研究
J Neurol Neurosurg Psychiatry. 1954 Aug;17(3):163-72. doi: 10.1136/jnnp.17.3.163.
5
Modification of the Marchi technic.马基技术的改良。
Stain Technol. 1954 Mar;29(2):71-5. doi: 10.3109/10520295409115444.
6
Experimental demyelination with organo-phosphorus compounds.有机磷化合物所致实验性脱髓鞘
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