单次接种灭活甲肝脂质体疫苗仅两周后就能诱导产生保护性抗体。
A single vaccination with an inactivated hepatitis A liposome vaccine induces protective antibodies after only two weeks.
作者信息
Just M, Berger R, Dreschsler H, Brantschen S, Glück R
机构信息
University Children's Hospital, Basel, Switzerland.
出版信息
Vaccine. 1992;10(11):737-9. doi: 10.1016/0264-410x(92)90506-f.
In the near future an inactivated hepatitis A vaccine will be commercially available. The recommended vaccination schedule will include at least two vaccinations 1 month apart. Giving two doses of vaccine on the same day in one injection results in protection after 2-4 weeks dependent on the adjuvant used. Hepatitis A virus incorporated into liposomes proved to be a suitable formulation in term of rapid seroconversion, high level of mean antibody content and low reactogenicity.
在不久的将来，一种灭活甲型肝炎疫苗将投入商业使用。推荐的疫苗接种程序将包括至少两次间隔1个月的接种。在同一天通过一次注射给予两剂疫苗，根据所使用的佐剂不同，2至4周后可产生保护作用。就快速血清转化、高平均抗体含量水平和低反应原性而言，脂质体包裹的甲型肝炎病毒被证明是一种合适的制剂。
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