Pasternack B S, Shore R E, Albert R E
J Occup Med. 1977 Nov;19(11):741-6.
This industry-wide epidemiologic study to evaluate the human carcinogenicity of the chloromethyl ethers (CME) included 1827 CME-exposed workers and 8870 controls. Duration and relative intensity of exposure were classified by job description in the personnel records. This information permitted assigning relative magnitude of exposure scores for each job category at several plants, with allowance for temporal changes in the plant processes. Social security records were used for the ascertainment of deaths among separated employees. Death certificates were obtained for virtually all known deaths, and hospital pathology reports were obtained where possible for the cancer-related deaths. No differences in noncancer death rates were found. An increased risk of respiratory cancer death in CME-exposed workers was found at only one firm where high exposures are known to have occurred. A clear dose-response relationship with risk ratios exceeding ten for the longest duration and greatest exposure subgroups was demonstrated for this firm.
这项评估氯甲基醚（CME）对人类致癌性的全行业流行病学研究纳入了1827名接触CME的工人和8870名对照者。根据人事记录中的工作描述对接触的持续时间和相对强度进行分类。这些信息使得能够为几家工厂的每个工作类别确定接触分数的相对大小，并考虑到工厂生产过程中的时间变化。利用社会保障记录确定离职员工的死亡情况。几乎所有已知死亡者都获取了死亡证明，对于与癌症相关的死亡，尽可能获取了医院病理报告。未发现非癌症死亡率存在差异。仅在一家已知曾发生高暴露的公司中，发现接触CME的工人呼吸道癌死亡风险增加。对于该公司，在最长接触持续时间和最大暴露亚组中，显示出明确的剂量反应关系，风险比超过10。
