Stelzner F
Zentrum für operative Medizin, Friedrich-Wilhelms-Universität, Bonn.
Zentralbl Chir. 1992;117(9):471-5.
The generally-favoured polyp-cancer sequence hypothesis its probably wrong. The distribution of polyps in large intestine differs from that of cancer. There is evidence that different aetiological factors are involved in the genesis of polyps, their growth rate and the development to invasive cancer. Most polyps are very small (90%). They never develop a cancer. It is a diffusely abnormal state of the large bowel mucosa which renders it more liable to produce often polyps and very rare carcinoma (5%). Polyp-carcinoma concomitance is much nearer to the truth.
普遍受到青睐的息肉-癌症序列假说可能是错误的。息肉在大肠中的分布与癌症不同。有证据表明，息肉的发生、生长速度以及发展为浸润性癌症涉及不同的病因学因素。大多数息肉非常小（90%）。它们从不发展为癌症。大肠黏膜处于弥漫性异常状态，这使其更容易产生息肉，而产生癌的情况非常罕见（5%）。息肉与癌并存的说法更接近事实。
