Kaiser H, Niesel H C, Biscoping J, al-Rafai S, Klimpel L
Department of Anaesthesiology, St. Marien- and St. Annastiftskrankenhaus, Ludwigshafen, FRG.
Acta Anaesthesiol Scand. 1992 Oct;36(7):689-91. doi: 10.1111/j.1399-6576.1992.tb03545.x.
In a pharmacokinetic study of combined sciatic/3-in-1 block for lower limb surgery, the two moderate-acting local anaesthetics prilocaine and mepivacaine were compared. The mean maximum venous plasma concentrations of mepivacaine were more than twice as high as when prilocaine was used as anaesthetic (5.1 micrograms/ml vs. 2.37 micrograms/ml). When used in combination with the former, ornipressin did not reduce plasma concentrations of mepivacaine to values which were below the threshold for toxic symptoms (5-6 mg/ml). The peak plasma concentrations exceeded the threshold of 5 micrograms/ml in four of the nine patients of the mepivacaine group (maximum value 7.21 mg/ml) and in two of the nine patients of the mepivacaine+ornipressin group (maximum value 8.61 micrograms/ml).
在一项关于下肢手术联合坐骨神经阻滞/三合一阻滞的药代动力学研究中，对两种中效局部麻醉药丙胺卡因和甲哌卡因进行了比较。甲哌卡因的平均最大静脉血浆浓度比使用丙胺卡因作为麻醉药时高出两倍多（5.1微克/毫升对2.37微克/毫升）。当与前者联合使用时，奥曲肽并未将甲哌卡因的血浆浓度降低至低于毒性症状阈值（5 - 6毫克/毫升）的值。在甲哌卡因组的9名患者中有4名（最大值7.21毫克/毫升）以及甲哌卡因 + 奥曲肽组的9名患者中有2名（最大值8.61微克/毫升）的血浆峰值浓度超过了5微克/毫升的阈值。
