Anderlik P, Bános Z, Szeri I, Barna Z
Semmelweis Orvostudományi Egyetem Mikrobiológiai Intézet, Budapest.
Acta Pharm Hung. 1992 Jul;62(4):167-71.
Balb/c (euthymic) and nu/nu (athymic) mice were treated intraperitoneally with TP-4 (a synthetic tetrapeptide, thymopoietin sequence analog, Pharmaceutical Product's Factory Gedeon Richter, Budapest, Hungary) or with Mannozym (0.1% zymosan suspension, Institute for Serobacterological Production and Research, HUMAN, Budapest, Hungary), and were infected intracerebrally with LCM virus. Both of the agents contributed to the development of fatal choriomeningitis, consequently they stimulated the cellular immune response in euthymic mice, but the athymic mice, either treated or not, survived the infection, consequently the agents had no effect on the course of LCM virus infection. The results showed that the cellular immune response stimulating effect by both agents was thymus-dependent. Using these agents immunostimulatory effect can be realized only in the presence of the thymus or the T-dependent lymphoid system, respectively.
将Balb/c（正常胸腺）和nu/nu（无胸腺）小鼠腹腔注射TP-4（一种合成四肽，胸腺生成素序列类似物，匈牙利布达佩斯吉东·里奇特制药厂生产）或甘露聚糖酶（0.1%酵母聚糖悬浮液，匈牙利布达佩斯人类血清细菌学生产与研究所生产），然后脑内接种淋巴细胞脉络丛脑膜炎病毒（LCM病毒）。两种制剂都导致了致命性脉络丛脑膜炎的发生，因此它们在正常胸腺小鼠中刺激了细胞免疫反应，但无论是否接受治疗，无胸腺小鼠都在感染中存活下来，因此这些制剂对LCM病毒感染的进程没有影响。结果表明，两种制剂的细胞免疫反应刺激作用均依赖于胸腺。分别使用这些制剂时，只有在胸腺或T细胞依赖的淋巴系统存在的情况下，才能实现免疫刺激作用。
