Ganzer U, Arnold W
Laryngol Rhinol Otol (Stuttg). 1977 Oct;56(10):850-9.
Audiometric recordings of children suffering from chronic mucous effusion of the middle ear have revealed a statistically significant and permanent sensorineural hearing loss of high frequences. Attemps for mechanical or physical factors as explanation are not convincing. We believe that inner ear disturbances in chronic mucous effusion rise by direct intoxication of the basal turns of the cochlea caused by pathologic alterations of mucous membrane tissue. Certain substances like lysozymes or histamine are supposed to diffuse via round window membrane to the inner ear. On the other hand mucous effusion which fills the middle cavity prevents oxygen to diffuse from the middle ear to the inner ear. Maass et al. (1976) and Morgenstern (1977) clearly have shown that under physiological conditions oxygen tension in the perilymph of the basal cochlear turn partly depends on diffusion from the middle ear. The results of our clinical observations indicate that early diagnosis and prompt treatment is necessary to prevent permanent sensorineural hearing loss of high frequencies, especially in infants and children.
对患有中耳慢性黏液性积液的儿童进行的听力测定记录显示，高频段存在具有统计学意义的永久性感音神经性听力损失。试图用机械或物理因素来解释并不令人信服。我们认为，慢性黏液性积液中的内耳紊乱是由黏膜组织的病理改变导致耳蜗基底转直接中毒引起的。某些物质，如溶菌酶或组胺，被认为会通过圆窗膜扩散到内耳。另一方面，充满中耳腔的黏液性积液会阻止氧气从中耳扩散到内耳。马斯等人（1976年）和摩根施特恩（1977年）已明确表明，在生理条件下，耳蜗基底转外淋巴中的氧张力部分取决于从中耳的扩散。我们的临床观察结果表明，早期诊断和及时治疗对于预防高频段永久性感音神经性听力损失是必要的，尤其是在婴儿和儿童中。
