抗坏血酸缺乏对胆汁酸生物合成干扰的定位
Localization of the interference of ascorbic acid deficiency with bile acid biogenesis.
作者信息
Ginter E, Ozdín L, Nemec R
出版信息
Physiol Bohemoslov. 1977 Aug;26(4):353-9.
The catabolism of 26-14C-cholesterol and of 26-14C-7alpha-hydroxycholesterol, the first stage in the transformation of cholesterol to bile acids, was studied in guinea-pigs with chronic latent vitamin C deficiency. Vitamin C deficiency markedly inhibited the oxidation of 26-14C-cholesterol to 14CO2, but did not significantly affect the catabolism of 26-14C-7alpha-hydroxycholesterol. The distribution of 14C in the tissues and body fluids of control and vitamin-deficient guinea pigs injected with labelled 7alpha-hydroxycholesterol was likewise the same. Ascorbic acids is probably needed only for 7alpha-hydroxylation of cholesterol, while the other stages of bile acid biogenesis are independent of vitamin C.
在患有慢性潜在维生素C缺乏症的豚鼠中，研究了26-¹⁴C-胆固醇和26-¹⁴C-7α-羟基胆固醇（胆固醇转化为胆汁酸的第一阶段）的分解代谢。维生素C缺乏显著抑制了26-¹⁴C-胆固醇氧化为¹⁴CO₂，但对26-¹⁴C-7α-羟基胆固醇的分解代谢没有显著影响。注射了标记的7α-羟基胆固醇的对照豚鼠和维生素缺乏豚鼠的组织和体液中¹⁴C的分布同样相同。可能仅在胆固醇的7α-羟基化过程中需要抗坏血酸，而胆汁酸生物合成的其他阶段与维生素C无关。
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