Hosal I N, Onerci M, Kaya S, Turan E
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Am J Otolaryngol. 1992 Nov-Dec;13(6):363-5. doi: 10.1016/0196-0709(92)90077-7.
Most patients with squamous cell carcinoma of the lower lip present with early disease and follow a rather indolent clinical course. Determinant 5-year survival rates range from 85% to 95%. This study was undertaken in an attempt to gain insight into the cause of failure in those few patients who develop recurrent disease.
A retrospective review was completed on patients treated between 1964 and 1990. Patients were staged according to the American Joint Committee. Patients with no palpable adenopathy had either a unilateral or bilateral suprahyoid dissection performed. Patients with palpable adenopathy underwent radical neck dissection. All patients were followed for evidence of recurrent disease.
The records of 92 patients treated surgically for squamous cell carcinoma of the lower lip were available and complete. Palpable adenopathy was present in 38 patients; however, only 8 of these patients (21%) were histologically positive. Of the 54 patients judged to be free of disease, 3 (5.5%) had histologic evidence of metastasis. Overall, the incidence of cervical metastasis was 12%.
The incidence of cervical metastasis in patients with squamous cell carcinoma of the lip is low; however, these data suggest that the size of the primary tumor does not correlate closely with predicting the incidence of regional lymph node metastases.
大多数下唇鳞状细胞癌患者就诊时处于疾病早期，临床病程较为缓慢。5年生存率的决定性范围为85%至95%。本研究旨在深入了解少数复发患者的失败原因。
对1964年至1990年间接受治疗的患者进行了回顾性研究。患者根据美国联合委员会进行分期。无可触及淋巴结肿大的患者进行了单侧或双侧舌骨上区清扫术。有可触及淋巴结肿大的患者接受了根治性颈清扫术。所有患者均随访有无复发疾病的证据。
有92例接受手术治疗的下唇鳞状细胞癌患者的记录可用且完整。38例患者有可触及的淋巴结肿大；然而，其中只有8例患者（21%）组织学检查呈阳性。在54例被判定无疾病的患者中，3例（5.5%）有转移的组织学证据。总体而言，颈部转移的发生率为12%。
唇部鳞状细胞癌患者颈部转移的发生率较低；然而，这些数据表明，原发肿瘤的大小与预测区域淋巴结转移的发生率并无密切关联。
