异烟酰异丙肼治疗癫痫白痴患者的临床观察

Clinical observations on iproniazid in idiots with epilepsy.

作者信息

REBHUN J

出版信息

Calif Med. 1960 Mar;92(3):207-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1578148/

Abstract

In contradistinction to the observation made before that iproniazid has a potentiating effect on certain amines in guinea pigs, human studies have shown that this effect has very little clinical importance, when both the amines and the amine oxidase inhibitor are given in the usual therapeutic doses. However, neither in man nor in the guinea pig pretreatment with iproniazid showed a potentiating effect on amines which are not substrates of monoamine oxidase (ephedrine and amphetamine). Patients with epilepsy and allergic disease may receive iproniazid.

摘要

与之前观察到的异烟酰异丙肼对豚鼠体内某些胺类有增强作用相反，人体研究表明，当胺类和胺氧化酶抑制剂都以常规治疗剂量给药时，这种作用在临床上几乎没有重要意义。然而，无论是在人体还是在豚鼠中，用异烟酰异丙肼预处理对不是单胺氧化酶底物的胺类（麻黄碱和苯丙胺）均未显示出增强作用。癫痫患者和过敏性疾病患者可以使用异烟酰异丙肼。

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