Renversez J C, Alzieu C, Vernet M
Laboratoire de biochimie A, CHRU de Grenoble, France.
Ann Biol Clin (Paris). 1992;50(1):1-7.
Chronical alcohol ingestion may induce conformational molecular modifications of plasma transferrin: alcohol modifies the content of its carbohydrates. The abnormal transferrin contains reduced amounts of carbohydrates, especially sialic acid, constituting its terminal trisaccharides biantennary chains. Plasma levels of partly deficient or asialotransferrin increase in chronically drinkers. In English speaking countries, it is called carbohydrate deficient transferrin or CDT. A positive correlation is obtained between the plasmatic concentration of CDT and the amount of ingested alcohol. Positivity and sensitivity of CDT are superior to those other usual biological parameters. The CDT quantitation may be proposed for the detection and the follow-up of alcohol drinkers, in order to evaluate the degree of intoxication, and during the period of withdrawal.
酒精会改变其碳水化合物含量。异常转铁蛋白的碳水化合物含量减少，尤其是构成其末端三糖双天线链的唾液酸。长期饮酒者血浆中部分缺乏或无唾液酸转铁蛋白的水平会升高。在英语国家，它被称为碳水化合物缺乏转铁蛋白或CDT。CDT的血浆浓度与酒精摄入量之间呈正相关。CDT的阳性率和敏感性优于其他常用的生物学参数。可以通过检测CDT来检测和跟踪饮酒者，以评估中毒程度以及戒酒期间的情况。
