Boccuzzi G, Aragno M, Brignardello E, Tamagno E, Conti G, Di Monaco M, Racca S, Danni O, Di Carlo F
Department of Clinical Pathophysiology, University of Turin, Torino, Italy.
Anticancer Res. 1992 Sep-Oct;12(5):1479-83.
The effect of dehydroepiandrosterone (DHEA) (2 mg, twice daily p.o.) on the growth of the dimethylbenz (a) anthracene (DMBA)-induced mammary carcinoma was studied in intact and ovariectomized adult female rats. DHEA treatment stimulated the tumor growth in ovariectomized animals. Conversely, the tumors of intact rats treated with DHEA progressed to a lesser extent than those of intact untreated animals (p < 0.01). Plasma levels of DHEA were higher in DHEA-fed than in untreated animals (p < .01), whereas E2 concentrations were unchanged after DHEA administration. Estrogen receptor (ER) concentrations in tumor tissue of ovariectomized animals given DHEA were no different form those found in intact rats, whereas ER were undetectable in untreated ovariectomized rats. The data indicate that DHEA stimulates the growth of DMBA-induced mammary tumors in ovariectomized rats, while it reduces the tumor progression in intact animals.
在完整和去卵巢的成年雌性大鼠中，研究了脱氢表雄酮（DHEA）（2毫克，口服，每日两次）对二甲基苯并（a）蒽（DMBA）诱导的乳腺癌生长的影响。DHEA治疗刺激了去卵巢动物的肿瘤生长。相反，用DHEA治疗的完整大鼠的肿瘤进展程度低于未治疗的完整动物（p<0.01）。喂食DHEA的动物血浆中DHEA水平高于未治疗的动物（p<.01），而给予DHEA后E2浓度未改变。给予DHEA的去卵巢动物肿瘤组织中的雌激素受体（ER）浓度与完整大鼠中的无差异，而在未治疗的去卵巢大鼠中未检测到ER。数据表明，DHEA刺激去卵巢大鼠中DMBA诱导的乳腺肿瘤生长，而在完整动物中它减少肿瘤进展。
