van Tellingen O, Sips J H, Beijnen J H, Bult A, Nooijen W J
Department of Clinical Chemistry, Netherlands Cancer Institute, Amsterdam.
Anticancer Res. 1992 Sep-Oct;12(5):1699-715.
Vinca alkaloids have been used as chemotherapeutic agents now for over three decades. Especially during recent years, the development of a considerable number of semi-synthetic derivatives, showing attractive properties in preclinical or clinical investigations, has been reported. In this paper we shall give a critical review of the investigations presented on this matter.