红平红球菌HL 24-2在苦味酸分解代谢过程中的初始氢化作用。
Initial hydrogenation during catabolism of picric acid by Rhodococcus erythropolis HL 24-2.
作者信息
Lenke H, Knackmuss H J
机构信息
Institut für Mikrobiologie, Universität Stuttgart, Germany.
出版信息
Appl Environ Microbiol. 1992 Sep;58(9):2933-7. doi: 10.1128/aem.58.9.2933-2937.1992.
Abstract
Rhodococcus erythropolis HL 24-2, which was originally isolated as a 2,4-dinitrophenol-degrading bacterium, could also utilize picric acid as a nitrogen source after spontaneous mutation. During growth, the mutant HL PM-1 transiently accumulated an orange-red metabolite, which was identified as a hydride-Meisenheimer complex of picric acid. This complex was formed as the initial metabolite and further converted with concomitant liberation of nitrite. 2,4,6-Trinitrocyclohexanone was identified as a dead-end metabolite of the degradation of picric acid, indicating the addition of two hydride ions to picric acid.
摘要
红平红球菌HL 24-2最初是作为一种降解2,4-二硝基苯酚的细菌分离得到的，经自发突变后也能利用苦味酸作为氮源。在生长过程中，突变体HL PM-1短暂积累了一种橙红色代谢产物，该产物被鉴定为苦味酸的氢化物-迈森海默络合物。这种络合物作为初始代谢产物形成，并随着亚硝酸盐的释放而进一步转化。2,4,6-三硝基环己酮被鉴定为苦味酸降解的终产物，表明向苦味酸中添加了两个氢离子。
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