Fass R J, Prior R B
Antimicrob Agents Chemother. 1977 Oct;12(4):551-4. doi: 10.1128/AAC.12.4.551.
The susceptibilities to spectinomycin of 303 recent urinary tract isolates were determined and compared to the susceptibilities of those strains to ampicillin, tetracycline, and gentamicin. Based on minimal inhibitory concentrations, 84% of Escherichia coli, Klebsiella, and Enterobacter, 31% of other Enterobacteriaceae, 7% of Staphylococcus aureus and Streptococcus (including enterococci), and 0% of Pseudomonas aeruginosa were susceptible to concentrations of spectinomycin that are easily surpassed in serum (</=32 mug/ml); 90% of all organisms tested other than P. aeruginosa were susceptible to concentrations that are easily surpassed in urine (</=128 mug/ml). Spectinomycin was active against more isolates than either ampicillin or tetracycline but against fewer isolates than gentamicin. Disk diffusion susceptibility tests did not reliably distinguish susceptible from resistant isolates with any of the four antibiotics studied.
测定了303株近期泌尿系统分离菌株对壮观霉素的敏感性，并将这些菌株对壮观霉素的敏感性与对氨苄西林、四环素和庆大霉素的敏感性进行了比较。根据最低抑菌浓度，84%的大肠杆菌、克雷伯菌和肠杆菌、31%的其他肠杆菌科细菌、7%的金黄色葡萄球菌和链球菌（包括肠球菌）以及0%的铜绿假单胞菌对血清中容易超过的壮观霉素浓度（≤32μg/ml）敏感；除铜绿假单胞菌外，90%的受试菌株对尿液中容易超过的浓度（≤128μg/ml）敏感。壮观霉素对分离菌株的活性比对氨苄西林或四环素更强，但比对庆大霉素弱。纸片扩散药敏试验无法可靠地区分所研究的四种抗生素中敏感和耐药的分离菌株。
