Walker B F, Someren A, Kennedy J C, Nicholas E M
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
Arch Pathol Lab Med. 1992 Nov;116(11):1217-20.
A 62-year-old woman who presented with urinary frequency and microscopic hematuria was found to have a 1.2 x 1.0 x 0.6-cm polypoid carcinoid tumor of the urinary bladder. The tissue resected from the base after removal of the polypoid lesion disclosed a small focus of residual carcinoid tumor, associated with Brunn's epithelial nests, cystitis cystica, and cystitis glandularis. Tumor cells exhibited strong argyrophilia and weak argentaffinity. Immunohistochemical staining reactions were strongly positive for chromogranin and serotonin, and electron microscopy revealed characteristic dense-core granules. Flow cytometric evaluation revealed an aneuploid cell population with a DNA index of 1.20.
一名62岁女性因尿频和镜下血尿就诊，被发现患有膀胱1.2×1.0×0.6厘米的息肉样类癌肿瘤。在切除息肉样病变后从基底切除的组织显示有一小片残留类癌肿瘤灶，伴有布伦上皮巢、囊性膀胱炎和腺性膀胱炎。肿瘤细胞显示强嗜银性和弱亲银性。免疫组化染色反应嗜铬粒蛋白和血清素呈强阳性，电子显微镜显示有特征性的致密核心颗粒。流式细胞术评估显示非整倍体细胞群，DNA指数为1.20。
