Frank G A, Kazesalu Ia S-V, Piĭrsoo A O, Litvinova L V, Vial'tsev N V
Arkh Patol. 1992;54(3):12-5.
Morphological assessment of two samples of monoclonal antibodies (mcAB) to gamma-unit of neurospecific human enolase (NSE) is performed. It is established that mcABs interact in the tissue sections with neurons of the brain and spinal cord, gangliocytes of the central and peripheral nervous system this proving their specificity. 56 cases of lung carcinoma are studied using these mcABs; endocrine carcinoma was found in 11 cases, nonendocrine--in 45 cases. Neuroendocrine differentiation is revealed in 8 of 45 cases of non-small cell carcinoma; in all observations of small cell carcinoma NSE was found.
对两种针对人神经特异性烯醇化酶（NSE）γ亚基的单克隆抗体（mcAB）进行了形态学评估。已证实，这些mcAB在组织切片中与脑和脊髓的神经元、中枢和外周神经系统的神经节细胞相互作用，这证明了它们的特异性。使用这些mcAB对56例肺癌病例进行了研究；发现11例为内分泌癌，45例为非内分泌癌。在45例非小细胞癌中有8例显示神经内分泌分化；在所有小细胞癌观察病例中均发现了NSE。
