HUMPHREY J H, TURK J L
Immunology. 1961 Oct;4(4):301-9.
A state of immunological unresponsiveness to bovine serum albumin (BSA) or human gamma globulin (HGG) can be produced in guinea pigs by contact with these proteins either before and soon after birth, or even soon after birth alone. As judged by failure of treated animals to show immune elimination of the antigen, or anaphylaxis on reinjection, the animals were completely unresponsive when tested up to 5 months after birth. Administration of 6-mercaptopurine to guinea pigs, even in lethal doses, did not prevent the development of antibodies to HGG. After administration of BSA or HGG, labelled with I, to pregnant guinea pigs, their offspring at term contained significant amounts of the labelled proteins. HGG was catabolized in new-born guinea pigs with the same half-life as in adults.
在豚鼠出生前及出生后不久,或仅在出生后不久接触牛血清白蛋白(BSA)或人γ球蛋白(HGG),均可使其产生对这些蛋白质的免疫无反应状态。根据处理过的动物未能表现出对抗原的免疫清除或再次注射时的过敏反应判断,这些动物在出生后长达5个月进行检测时完全无反应。给豚鼠注射6-巯基嘌呤,即使是致死剂量,也不能阻止其产生抗HGG抗体。给怀孕的豚鼠注射用碘标记的BSA或HGG后,其足月后代含有大量标记蛋白。HGG在新生豚鼠体内的分解代谢半衰期与成年豚鼠相同。