胸腺在大鼠免疫反应中的作用。I. 出生后不同时间进行胸腺切除或脾切除的大鼠对牛血清白蛋白的免疫反应（抗体形成、阿瑟斯反应和迟发型超敏反应）
Role of the thymus in immune ractions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth.
作者信息
JANKOVIC B D, WAKSMAN B H, ARNASON B G
出版信息
J Exp Med. 1962 Aug 1;116(2):159-76. doi: 10.1084/jem.116.2.159.
Rats thymectomized at birth gained weight and otherwise developed normally, but were found to be very susceptible to intercurrent infections. Both Arthus reactivity and delayed hypersensitivity to BSA were markedly impaired in rats thymectomized during the first week of life and significantly impaired in rats thymectomized as late as 3 weeks after birth. The inhibition of Arthus reactivity in thymectomized rats was well correlated with their failure to develop significant titers of precipitating or hemagglutinating antibody. However, natural heteroagglutinin titers were not altered in these animals, and no abnormality of serum proteins, including gamma-globulin could be detected by paper electrophoresis. The loss of immunologic activity could not be corrected by injecting homogenates of spleen or thymus before and during the sensitization period. Splenectomy at birth did not influence Arthus or delayed reactivity.
出生时即进行胸腺切除的大鼠体重增加，其他方面发育正常，但发现它们极易受到并发感染的影响。出生后第一周内进行胸腺切除的大鼠，其对牛血清白蛋白（BSA）的阿瑟斯反应性和迟发型超敏反应均明显受损；出生后晚至3周进行胸腺切除的大鼠，上述反应也显著受损。胸腺切除大鼠的阿瑟斯反应性受到抑制，这与它们无法产生显著滴度的沉淀抗体或血凝抗体密切相关。然而，这些动物的天然异种凝集素滴度并未改变，通过纸电泳也未检测到包括γ球蛋白在内的血清蛋白异常。在致敏期之前和期间注射脾脏或胸腺匀浆，无法纠正免疫活性的丧失。出生时进行脾切除并不影响阿瑟斯反应或迟发型反应。
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