Dupont G, Goldbeter A
Faculté des Sciences, Université Libre de Bruxelles, Belgium.
Bioessays. 1992 Jul;14(7):485-93. doi: 10.1002/bies.950140711.
Oscillations in cytosolic Ca2+ occur in a wide variety of cells, either spontaneously or as a result of external stimulation. This process is often accompanied by intracellular Ca2+ waves. A number of theoretical models have been proposed to account for the periodic generation and spatial propagation of Ca2+ signals. These models are reviewed and their predictions compared with experimental observations. Models for Ca2+ oscillations can be distinguished according to whether or not they rely on the concomitant, periodic variation in inositol 1,4,5-trisphosphate. Such a variation, however, is not required in models based on Ca(2+)-induced Ca2+ release. When Ca2+ diffusion is incorporated into these models, propagating waves of cytosolic Ca2+ arise, with profiles and rates comparable to those seen in the experiments.
胞质溶胶中Ca2+的振荡发生在各种各样的细胞中，要么是自发的，要么是外部刺激的结果。这个过程通常伴随着细胞内Ca2+波。已经提出了许多理论模型来解释Ca2+信号的周期性产生和空间传播。本文对这些模型进行了综述，并将它们的预测结果与实验观察结果进行了比较。Ca2+振荡模型可以根据它们是否依赖于肌醇1,4,5-三磷酸的伴随周期性变化来区分。然而，在基于Ca(2+)诱导的Ca2+释放的模型中，这种变化并不是必需的。当将Ca2+扩散纳入这些模型时，就会出现胞质溶胶Ca2+的传播波，其轮廓和速率与实验中观察到的相当。
