Sakai R, Shiozaki M, Tabuchi M, Eto Y
Basic Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
Biochem Biophys Res Commun. 1992 Oct 30;188(2):921-6. doi: 10.1016/0006-291x(92)91143-e.
Many studies have shown that activin/EDF mediates local physiological events at various sites. In this study, the authors confirmed the presence of activin in mouse serum by high performance liquid chromatography (HPLC) monitored by a specific bioassay. The retention time of the active fraction in HPLC was identical to that of authentic activin A, and the activity was neutralized by follistatin. That the serum activin levels in ovariectomized and aged mice were decreased suggests that the serum activin was generated partly by ovary (35%), but also by extragonadal organs. Activin and inhibin are structurally closely related, and both are involved in many physiological processes including control of follicle stimulating hormone secretion by the pituitary. The regulation of serum activin, however, appeared to differ from that of inhibin.
许多研究表明，激活素/促卵泡成熟素在多个部位介导局部生理活动。在本研究中，作者通过高效液相色谱法（HPLC）并采用特定生物测定法监测，证实了小鼠血清中存在激活素。HPLC中活性组分的保留时间与纯激活素A相同，且该活性被卵泡抑素中和。卵巢切除小鼠和老龄小鼠血清激活素水平降低，这表明血清激活素部分由卵巢产生（35%），但也由性腺外器官产生。激活素和抑制素在结构上密切相关，二者均参与包括垂体对促卵泡激素分泌的调控在内的许多生理过程。然而，血清激活素的调节似乎与抑制素不同。
